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KMID : 0366220160510040242
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Korean Journal of Hematology
2016 Volume.51 No. 4 p.242 ~ p.248
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Therapy-related myeloid neoplasms in children and adolescents
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Cho Hee-Won
Choi Young-Bae
Yi Eun-Sang
Lee Ji-Won
Sung Ki-Woong
Koo Hong-Hoe
Yoo Keon-Hee
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Abstract
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Background: This retrospective study aimed to characterize and analyze the outcome of therapy-related myeloid neoplasms (t-MNs) in children and adolescents.
Methods: The medical records of 16 patients under 21 years of age at the time of t-MN diagnosis were reviewed.
Results: The median patient age was 11.5 years (range, 1.6?20.4 yr). Twelve patients had therapy-related acute myeloid leukemia, 3 patients had myelodysplastic syndrome, and 1 patient had chronic myelomonocytic leukemia. The median latency period was 29 months (range, 11?68 mo). Fourteen patients had cytogenetic aberrations, 8 of whom had an 11q23 abnormality. Of the 13 patients treated with curative intent, 12 patients received myeloid-type induction therapy that led to complete remission (CR) in 8 patients. Nine patients underwent allogeneic transplantation; 4 patients did not undergo transplantation due to chemotherapy-related toxic death (N=3) or parental refusal (N=1). The 5-year overall survival and event-free survival of the 13 patients treated with a curative intent were 46.2% and 30.8%, respectively. For the 9 patients who underwent allogeneic transplantation, the 5-year event-free survival was 66.7%.
Conclusion: A significant proportion of young patients with t-MNs can experience long-term survival, and allogeneic transplantation plays a key role for attaining cure in these patients.
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KEYWORD
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Therapy-related myeloid neoplasms, Pediatric population, Allogeneic hematopoietic stem cell transplantation
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